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Sepn1tm1.2Mred
Targeted Allele Detail
Nomenclature
Symbol: Sepn1tm1.2Mred
Name: selenoprotein N, 1; targeted mutation 1.2, Mathieu Rederstorff
MGI ID: MGI:4946396
Gene: Sepn1  Location: Chr4:134537892-134552166 bp, - strand  Genetic Position: Chr4, 66.85 cM, cytoband D3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:168699
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 3. A floxed neo cassette was inserted downstream of exon 3. Cre-mediated recombination removed exon 3 and the neo cassette. Western blot analysis on skeletal muscle. heart, lung, liver, brain, and kidney extracts confirmed the absence of protein expression. (J:176499)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 19 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sepn1 Mutation:  10 strains or lines available
References
Original:  J:168699 Castets P, et al., Satellite cell loss and impaired muscle regeneration in selenoprotein N deficiency. Hum Mol Genet. 2011 Feb 15;20(4):694-704
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory