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Trp53tm8Xu
Targeted Allele Detail
Nomenclature
Symbol: Trp53tm8Xu
Name: transformation related protein 53; targeted mutation 8, Yang Xu
MGI ID: MGI:4946291
Synonyms: p53S18A/S23A, p53TSD
Gene: Trp53  Location: Chr11:69580359-69591873 bp, + strand  Genetic Position: Chr11, 42.83 cM, cytoband B2-C
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:170216
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsNucleotide substitutions (ACA and TCA to GAT) resulted in the amino acid substitutions of aspartic acid for threonine and serine at positions 21 and 23 (T21D and S23D). A floxed neo cassette was inserted downstream of exon 4. (J:170216)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trp53 Mutation:  150 strains or lines available
References
Original:  J:170216 Liu D, et al., Puma is required for p53-induced depletion of adult stem cells. Nat Cell Biol. 2010 Oct;12(10):993-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory