Trp53^tm8Xu
Targeted Allele Detail

Summary

• Symbol: Trp53^tm8Xu
• Name: transformation related protein 53; targeted mutation 8, Yang Xu
• MGI ID: MGI:4946291
• Synonyms: p53^S18A/S23A, p53^TSD
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm8Xu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170216
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Threonine codon 21 (ACA) and serine codon 23 (TCA) were changed to aspartic acid (GAT) (p.T21D and p.S23D). A loxP site flanked neomycin resistance gene cassette was inserted into intron 4. (J:170216)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 232 strains or lines available

References

• Original: J:170216 Liu D, et al., Puma is required for p53-induced depletion of adult stem cells. Nat Cell Biol. 2010 Oct;12(10):993-8
• All: 2 reference(s)