About   Help   FAQ
Targeted Allele Detail
Symbol: Nr1h3tm1.1Nph
Name: nuclear receptor subfamily 1, group H, member 3; targeted mutation 1.1, N P Hessvik
MGI ID: MGI:4946259
Gene: Nr1h3  Location: Chr2:91184061-91202829 bp, - strand  Genetic Position: Chr2, 50.52 cM
Germline Transmission:  Earliest citation of germline transmission: J:169945
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA floxed neo cassetted was inserted upstream of exon 2. A loxP site was inserted downstream of exon 7. Cre-mediated recombination removed exons 2 through 7 and the neo cassette. The absence of transcript expression was confirmed by RT-PCR. (J:169945)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nr1h3 Mutation:  9 strains or lines available
Original:  J:169945 Hessvik NP, et al., LXR{beta} is the dominant LXR subtype in skeletal muscle regulating lipogenesis and cholesterol efflux. Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E602-13
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.15
The Jackson Laboratory