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Hprt1tm5(Myh7-GFP,Myh6-CFP)Unc
Targeted Allele Detail
Summary
Symbol: Hprt1tm5(Myh7-GFP,Myh6-CFP)Unc
Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 5, University of North Carolina
MGI ID: MGI:4943867
Synonyms: aMHC-CFP
Gene: Hprt1  Location: ChrX:52077014-52110536 bp, + strand  Genetic Position: ChrX, 29.31 cM, cytoband A6
Alliance: Hprt1tm5(Myh7-GFP,Myh6-CFP)Unc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:139125
Parent Cell Line:  BK4 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to insert a 5.5 kb mouse Myh7 (bMHC) promoter driving a nuclear GFP, two copies of chicken beta globin HS4 insulators, a 5.6 kb mouse Myh6 (aMHC) promoter driving a cytoplasmic CFP and the human Hprt promoter (plus exons 1 and 2) upstream of mouse exon 3. CFP is expressed at low levels in the cells of day old mice, but at high levels in virtually all cells by postnatal day 10. GFP expression did not occur in adult cardiac myocytes. (J:139125)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hprt1 Mutation:  1272 strains or lines available
References
Original:  J:139125 Pandya K, et al., Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13063-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory