Tg(UGT1A1*28)1Rhtu
Transgene Detail

Summary

• Symbol: Tg(UGT1A1*28)1Rhtu
• Name: transgene insertion 1, Robert Tukey
• MGI ID: MGI:4943330
• Synonyms: Tg(UGT1^A1*28)Ugt1
• Transgene: Tg(UGT1A1*28)1Rhtu Location: unknown Genetic Position: Chr15, Syntenic
• Alliance: Tg(UGT1A1*28)1Rhtu page

Transgene origin

• Strain of Origin: (BALB/c x C57BL/6N)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(UGT1A1*28)1Rhtu expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  UGT1A1 (54658)

  Ugt1a1

  (MGI:98898)

• Mutation details: A transgene derived from a human bacterial artificial chromosome (BAC) library, containing the entire human UGT1 (UDP glucuronosyltransferase 1) complex, was modified by targeted mutation of the UGT1 polypeptide A1, UGT1A1, promoter to harbor the UGT1A1*28 mutation associated with hepatic dysfunction found in Gilbert's syndrome. Specifically, this mutation inserts an extra TA in the TATA box sequence of the UGTA1A promoter. Five founders were generated. Founder mice from line 1 carry 6 copies of the transgene on Chromosome 15. (J:102898)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:102898 Chen S, et al., Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus. J Biol Chem. 2005 Nov 11;280(45):37547-57
• All: 13 reference(s)