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Tg(UGT1A1*28)1Rhtu
Transgene Detail
Nomenclature
Symbol: Tg(UGT1A1*28)1Rhtu
Name: transgene insertion 1, Robert Tukey
MGI ID: MGI:4943330
Synonyms: Tg(UGT1A1*28)Ugt1
Transgene: Tg(UGT1A1*28)1Rhtu  Location: unknown  Genetic Position: Chr15, Syntenic
Transgene
origin
Strain of Origin:  (BALB/c x C57BL/6N)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(UGT1A1*28)1Rhtu expresses 1 gene
 
Mutation detailsA transgene derived from a human bacterial artificial chromosome (BAC) library, containing the entire human UGT1 (UDP glucuronosyltransferase 1) complex, was modified by targeted mutation of the UGT1 polypeptide A1, UGT1A1, promoter to harbor the UGT1A1*28 mutation associated with hepatic dysfunction found in Gilbert's syndrome. Specifically, this mutation inserts an extra TA in the TATA box sequence of the UGTA1A promoter. Five founders were generated. Founder mice from line 1 carry 6 copies of the transgene on Chromosome 15. (J:102898)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:102898 Chen S, et al., Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus. J Biol Chem. 2005 Nov 11;280(45):37547-57
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory