Plxdc2^tm1.1Mitc
Targeted Allele Detail

Summary

• Symbol: Plxdc2^tm1.1Mitc
• Name: plexin domain containing 2; targeted mutation 1.1, Kevin J Mitchell
• MGI ID: MGI:4941938
• Synonyms: Plxdc2::GFP,deltaneo
• Gene: Plxdc2 Location: Chr2:16361115-16760650 bp, + strand Genetic Position: Chr2, 11.8 cM
• Alliance: Plxdc2^tm1.1Mitc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:169456
• Parent Cell Line: CMTI-2 (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 5' splice substrate EGFP, polyadenylation sequence and floxed neo cassette replaced the coding region in exon 1 and intron 1. Cre-mediated recombination removed the neo cassette. A 10-fold reduction in transcript reduction was confirmed by RT-PCR. (J:169456)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plxdc2 Mutation: 29 strains or lines available

References

• Original: J:169456 Miller-Delaney SF, et al., Plxdc2 is a mitogen for neural progenitors. PLoS One. 2011;6(1):e14565
• All: 1 reference(s)