Selenok^tm1.1Itl
Targeted Allele Detail

Summary

• Symbol: Selenok^tm1.1Itl
• Name: selenoprotein K; targeted mutation 1.1, inGenious Targeting Laboratory
• MGI ID: MGI:4941877
• Synonyms: Sel K^fl, Selk^tm1.1Igl
• Gene: Selenok Location: Chr14:29690337-29697031 bp, + strand Genetic Position: Chr14, 18.36 cM
• Alliance: Selenok^tm1.1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:169169
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT- and loxP-flanked neo cassette was inserted upstream of exon 2. A loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the neo cassette. (J:169169)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Selenok Mutation: 14 strains or lines available

References

• Original: J:169169 Verma S, et al., Selenoprotein K knockout mice exhibit deficient calcium flux in immune cells and impaired immune responses. J Immunol. 2011 Feb 15;186(4):2127-37
• All: 1 reference(s)