P2ry6^tm1Brob
Targeted Allele Detail

Summary

• Symbol: P2ry6^tm1Brob
• Name: pyrimidinergic receptor P2Y, G-protein coupled, 6; targeted mutation 1, Bernard Robaye
• MGI ID: MGI:4941862
• Synonyms: P2Y6-eGFP
• Gene: P2ry6 Location: Chr7:100586837-100623856 bp, - strand Genetic Position: Chr7, 54.46 cM
• Alliance: P2ry6^tm1Brob page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:169742
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of the coding exon. An eGFP was inserted downstream of the coding exon. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of the coding exon. (J:169742)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any P2ry6 Mutation: 19 strains or lines available

References

• Original: J:169742 Bar I, et al., Knockout mice reveal a role for P2Y6 receptor in macrophages, endothelial cells, and vascular smooth muscle cells. Mol Pharmacol. 2008 Sep;74(3):777-84
• All: 5 reference(s)