Grem1^tm1.1Ecan
Targeted Allele Detail

Summary

• Symbol: Grem1^tm1.1Ecan
• Name: gremlin 1, DAN family BMP antagonist; targeted mutation 1.1, Ernesto Canalis
• MGI ID: MGI:4941469
• Gene: Grem1 Location: Chr2:113579020-113588993 bp, - strand Genetic Position: Chr2, 57.43 cM
• Alliance: Grem1^tm1.1Ecan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:237690
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (129X1/SvJ x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutations: Insertion, Intragenic deletion
• Mutation details: This allele was derived from Grem1^tm1Ecan by deletion of a frt -flanked selection cassette that, followed by a loxP site, replaced the non-conserved final 66 bp of the 3'-UTR. The present allele contains a loxP site 335 bp upstream of the coding region-encompassing second exon and, within exon 2, the remaining frt site and second loxP site 550 bp downstream of the termination codon. (J:169133)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grem1 Mutation: 19 strains or lines available

References

• Original: J:169133 Stafford DA, et al., Cooperative activity of noggin and gremlin 1 in axial skeleton development. Development. 2011 Mar;138(5):1005-14
• All: 2 reference(s)