Gli2tm2(Gli3)Blnw
Targeted Allele Detail
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Symbol: |
Gli2tm2(Gli3)Blnw |
Name: |
GLI-Kruppel family member GLI2; targeted mutation 2, Baolin Wang |
MGI ID: |
MGI:4941340 |
Gene: |
Gli2 Location: Chr1:118761862-118981349 bp, - strand Genetic Position: Chr1, 52.17 cM, cytoband E2-E4
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Alliance: |
Gli2tm2(Gli3)Blnw page
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Germline Transmission: |
Earliest citation of germline transmission:
J:169530
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Parent Cell Line: |
W4 (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The region coding for amino acid residues 585-751 was replaced with the corresponding region from mouse Gli3 and a floxed neo cassette was inserted via homologous recombination. The replaced region encodes for the processing determining domain.
(J:169530)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Gli2 Mutation: |
169 strains or lines available
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Original: |
J:169530 Li J, et al., Increased proteolytic processing of full-length Gli2 transcription factor reduces the hedgehog pathway activity in vivo. Dev Dyn. 2011 Apr;240(4):766-74 |
All: |
1 reference(s) |
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