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Lhx3tm1.1Sjr
Targeted Allele Detail
Nomenclature
Symbol: Lhx3tm1.1Sjr
Name: LIM homeobox protein 3; targeted mutation 1.1, Simon J Rhodes
MGI ID: MGI:4941330
Synonyms: Lhx3W227ter, Lhx3W227ter Neo(-)
Gene: Lhx3  Location: Chr2:26200212-26208249 bp, - strand  Genetic Position: Chr2, 18.44 cM, cytoband A2-C1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:169035
Parent Cell Line:  CCE916 (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Hypomorph)
Mutations:    Insertion, Single point mutation
 
Mutation detailsA floxed neo cassette was inserted and a tryptophan to stop mutation was introduced at amino acid 227 via homologous recombination. Cre mediated recombination removed the neo cassette. This mutation results in a truncated protein that lacks the carboxyl terminus. (J:169035)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lhx3 Mutation:  23 strains or lines available
References
Original:  J:169035 Colvin SC, et al., Model of pediatric pituitary hormone deficiency separates the endocrine and neural functions of the LHX3 transcription factor in vivo. Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):173-8
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory