Tg(tetO-ABL1*P242E*P249E)CPdav
Transgene Detail
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Symbol: |
Tg(tetO-ABL1*P242E*P249E)CPdav |
Name: |
transgene insertion C, Peter Davies |
MGI ID: |
MGI:4940842 |
Synonyms: |
AblPP, c-AblPP, TRE-AblPP, TRE-c-AblPP |
Transgene: |
Tg(tetO-ABL1*P242E*P249E)CPdav Location: unknown
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Alliance: |
Tg(tetO-ABL1*P242E*P249E)CPdav page
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Transgene Type: |
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Transgenic (Constitutively active, Humanized sequence, Inducible, Inserted expressed sequence) |
Inducer: |
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doxycycline/tetracycline |
Mutation: |
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Insertion
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Tg(tetO-ABL1*P242E*P249E)CPdav expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
ABL1 (25) |
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Tg(tetO-ABL1*P242E*P249E)CPdav expression driven by
1 gene
Transgene expression driven by:
Organism |
Driver Gene |
Note |
Not Specified |
tetO |
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Mutation details: The TRE-AblPP transgene was designed with a Tet response element (TRE) followed by a constitutively active c-Abl sequence (AblPP) and a beta-globin polyA sequence. The Tet response element (TRE) contains seven copies of the 42-bp tet operator sequence (tetO) just upstream of a minimal CMV promoter. To generate the AblPP sequence, a cDNA sequence encoding the nuclear-localizing isoform (1b) of the human c-Abl (ABL1; c-abl oncogene 1, non-receptor tyrosine kinase) was modified via site-directed mutagenesis to change the conserved proline residues of the SH2-SH3 linker region to glutamate (P242E/P249E).
(J:169520)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:169520 Schlatterer SD, et al., Neuronal c-Abl Overexpression Leads to Neuronal Loss and Neuroinflammation in the Mouse Forebrain. J Alzheimers Dis. 2011 Mar 2;25(1):119-133 |
All: |
1 reference(s) |
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