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Transgene Detail
Symbol: Tg(tetO-ABL1*P242E*P249E)CPdav
Name: transgene insertion C, Peter Davies
MGI ID: MGI:4940842
Synonyms: AblPP, c-AblPP, TRE-AblPP, TRE-c-AblPP
Transgene: Tg(tetO-ABL1*P242E*P249E)CPdav  Location: unknown  
Strain of Origin:  FVB/NTac
Transgene Type:    Transgenic (Constitutively active, Humanized sequence, Inducible, Inserted expressed sequence)
Mutation:    Insertion
Tg(tetO-ABL1*P242E*P249E)CPdav expresses 1 gene
Mutation detailsThe TRE-AblPP transgene was designed with a Tet response element (TRE) followed by a constitutively active c-Abl sequence (AblPP) and a beta-globin polyA sequence. The Tet response element (TRE) contains seven copies of the 42-bp tet operator sequence (tetO) just upstream of a minimal CMV promoter. To generate the AblPP sequence, a cDNA sequence encoding the nuclear-localizing isoform (1b) of the human c-Abl (ABL1; c-abl oncogene 1, non-receptor tyrosine kinase) was modified via site-directed mutagenesis to change the conserved proline residues of the SH2-SH3 linker region to glutamate (P242E/P249E). (J:169520)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:169520 Schlatterer SD, et al., Neuronal c-Abl Overexpression Leads to Neuronal Loss and Neuroinflammation in the Mouse Forebrain. J Alzheimers Dis. 2011 Mar 2;25(1):119-133
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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