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Tg(WAPT121)66Tvd
Transgene Detail
Nomenclature
Symbol: Tg(WAPT121)66Tvd
Name: transgene insertion 66, Terry van Dyke
MGI ID: MGI:4940590
Synonyms: TgWAP-T121, Tg(WAPT121)66Tvd, WAP-T121, WAP-T121 line 3
Transgene: Tg(WAPT121)66Tvd  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6J x DBA/2J)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThis transgene expresses T-121, a truncated form of the SV40 T-antigen that contains the first 121 amino acids. This form inactivates the RB1 protein and the two Rb1-related proteins, RBL1 and RBL2. The transgene is under the control of the mouse Wap promoter. This line carries approximately 10 copies of the transgene.
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:88315 Simin K, et al., pRb Inactivation in Mammary Cells Reveals Common Mechanisms for Tumor Initiation and Progression in Divergent Epithelia. PLoS Biol. 2004 Feb;2(2):E22
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory