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Transgene Detail
Symbol: Tg(WAPT121)66Tvd
Name: transgene insertion 66, Terry van Dyke
MGI ID: MGI:4940590
Synonyms: TgWAP-T121, Tg(WAPT121)66Tvd, WAP-T121, WAP-T121 line 3
Transgene: Tg(WAPT121)66Tvd  Location: unknown  
Strain of Origin:  (C57BL/6J x DBA/2J)F1
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Mutation detailsThis transgene expresses T-121, a truncated form of the SV40 T-antigen that contains the first 121 amino acids. This form inactivates the RB1 protein and the two Rb1-related proteins, RBL1 and RBL2. The transgene is under the control of the mouse Wap promoter. This line carries approximately 10 copies of the transgene.
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:88315 Simin K, et al., pRb Inactivation in Mammary Cells Reveals Common Mechanisms for Tumor Initiation and Progression in Divergent Epithelia. PLoS Biol. 2004 Feb;2(2):E22
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory