Tg(WAPT121)66Tvd
Transgene Detail

Summary

• Symbol: Tg(WAPT121)66Tvd
• Name: transgene insertion 66, Terry van Dyke
• MGI ID: MGI:4940590
• Synonyms: TgWAP-T121, Tg(WAPT121)66Tvd, WAP-T121, WAP-T121 line 3
• Transgene: Tg(WAPT121)66Tvd Location: unknown
• Alliance: Tg(WAPT121)66Tvd page

Transgene origin

• Strain of Origin: (C57BL/6J x DBA/2J)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: This transgene expresses T-121, a truncated form of the SV40 T-antigen that contains the first 121 amino acids. This form inactivates the RB1 protein and the two Rb1-related proteins, RBL1 and RBL2. The transgene is under the control of the mouse Wap promoter. This line carries approximately 10 copies of the transgene.

Tumor Data

List all tumor models in MMHCdb carrying Tg(WAPT121)66Tvd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:88315 Simin K, et al., pRb Inactivation in Mammary Cells Reveals Common Mechanisms for Tumor Initiation and Progression in Divergent Epithelia. PLoS Biol. 2004 Feb;2(2):E22
• All: 3 reference(s)