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Tg(Prnp-ATXN3*79Q)#Hlw
Transgene Detail
Nomenclature
Symbol: Tg(Prnp-ATXN3*79Q)#Hlw
Name: transgene insertion, Hung-Li Wang
MGI ID: MGI:4940057
Synonyms: Ataxin-3-Q79
Transgene: Tg(Prnp-ATXN3*79Q)#Hlw  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Prnp-ATXN3*79Q)#Hlw expresses 1 gene
 
Mutation detailsThe mouse promoter drive neuronal expression of the HA-tagged human cDNA with a trinucleotide repeat that results in a 79 glutamine stretch. This amplification of the glutamine tract is associated with Spinocerebellar Ataxia 3 (SCA3) in humans. Two lines with more than five copies of the transgene were generated. The pound symbol (#) denotes when no line number is specified and/or lines are pooled. (J:138381)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:138381 Chou AH, et al., Polyglutamine-expanded ataxin-3 causes cerebellar dysfunction of SCA3 transgenic mice by inducing transcriptional dysregulation. Neurobiol Dis. 2008 Jul;31(1):89-101
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory