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Mbtd1tm1Homy
Targeted Allele Detail
Nomenclature
Symbol: Mbtd1tm1Homy
Name: mbt domain containing 1; targeted mutation 1, Hiroaki Honda
MGI ID: MGI:4940055
Synonyms: Hemp-
Gene: Mbtd1  Location: Chr11:93885852-93946985 bp, + strand  Genetic Position: Chr11, 58.86 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:169112
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 6, 7, and 8 were replaced with an IRES GFP and a floxed neomycin resistance gene. The selection cassette was subsequently removed by cre mediated recombination. This removes the four "malignant brain tumor" domains. Western blot analysis demonstrated that no protein product was produced. (J:169112)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mbtd1 Mutation:  45 strains or lines available
References
Original:  J:169112 Honda H, et al., Hemp, an mbt domain-containing protein, plays essential roles in hematopoietic stem cell function and skeletal formation. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2468-73
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2020
MGI 6.16
The Jackson Laboratory