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Targeted Allele Detail
Symbol: Vti1atm1Gfvm
Name: vesicle transport through interaction with t-SNAREs 1A; targeted mutation 1, Gabriele Fischer von Mollard
MGI ID: MGI:4940029
Gene: Vti1a  Location: Chr19:55316295-55627309 bp, + strand  Genetic Position: Chr19, 51.35 cM, cytoband D2
Germline Transmission:  Earliest citation of germline transmission: J:169107
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neo cassette was inserted into exon 6, which encodes part of the SNARE motif. The absence of protein expression was confirmed by western blot analysis on E18.5 brain extracts. (J:169107)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 33 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vti1a Mutation:  46 strains or lines available
Original:  J:169107 Kunwar AJ, et al., Lack of the endosomal SNAREs vti1a and vti1b led to significant impairments in neuronal development. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2575-80
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory