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Ren1tm1.2Sig
Targeted Allele Detail
Nomenclature
Symbol: Ren1tm1.2Sig
Name: renin 1 structural; targeted mutation 1.2, Curt Sigmund
MGI ID: MGI:4939806
Synonyms: sRen-
Gene: Ren1  Location: Chr1:133350510-133360325 bp, + strand  Genetic Position: Chr1, 57.91 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:169129
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  C57BL/6J-Tyrc-2J
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCre-mediated recombination of Ren1tm1.1Sig removed exon 1a (Ia). The absence of the transcript encoding the secreted isoform was confirmed by RT-PCR. Expression of the transcript encoding the intracellular isoform is maintained. (J:169129)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ren1 Mutation:  5 strains or lines available
Notes
ES cell = SCR (C57BL/6J-Tyrc-2J)

References
Original:  J:169129 Xu D, et al., Preservation of intracellular renin expression is insufficient to compensate for genetic loss of secreted renin. Hypertension. 2009 Dec;54(6):1240-7
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory