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Targeted Allele Detail
Symbol: Ren1tm1.1Sig
Name: renin 1 structural; targeted mutation 1.1, Curt Sigmund
MGI ID: MGI:4939805
Synonyms: sRENflox
Gene: Ren1  Location: Chr1:133350674-133360320 bp, + strand  Genetic Position: Chr1, 57.91 cM
Germline Transmission:  Earliest citation of germline transmission: J:169129
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  C57BL/6J-Tyrc-2J
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsAn FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 1a (Ia). An additional loxP site was inserted downstream of exon 1a (Ia). Flp-mediated recombination removed the neo cassette leaving exon 1a (Ia) floxed. (J:169129)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ren1 Mutation:  7 strains or lines available
ES cell = SCR (C57BL/6J-Tyrc-2J)
Original:  J:169129 Xu D, et al., Preservation of intracellular renin expression is insufficient to compensate for genetic loss of secreted renin. Hypertension. 2009 Dec;54(6):1240-7
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory