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Targeted Allele Detail
Symbol: Elmo1tm1a(EUCOMM)Wtsi
Name: engulfment and cell motility 1; targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID: MGI:4939780
Gene: Elmo1  Location: Chr13:20090596-20608353 bp, + strand  Genetic Position: Chr13, 7.21 cM, cytoband A3.1
Mutant Cell Lines:  EPD0716_1_E03, EPD0716_1_G02, EPD0790_5_A01, EPD0790_5_A02, EPD0790_5_A03, EPD0790_5_A04, EPD0790_5_A08, EPD0790_5_A09, EPD0790_5_A11, EPD0790_5_A12, EPD0790_5_B01, EPD0790_5_B02, EPD0790_5_B05, EPD0790_5_B10, EPD0790_5_B11, EPD0790_5_B12, EPD0790_5_C02, EPD0790_5_C04, EPD0790_5_C05, EPD0790_5_C06, EPD0790_5_C10, EPD0790_5_C12, EPD0790_5_D02, EPD0790_5_D07, EPD0790_5_D09, EPD0790_5_D11, EPD0790_5_D12, EPD0790_5_E01, EPD0790_5_E04, EPD0790_5_E06, EPD0790_5_E09, EPD0790_5_F01, EPD0790_5_F02, EPD0790_5_F03, EPD0790_5_F05, EPD0790_5_F07, EPD0790_5_F09, EPD0790_5_F10, EPD0790_5_G02, EPD0790_5_G03, EPD0790_5_G05, EPD0790_5_G06, EPD0790_5_G07, EPD0790_5_G09, EPD0790_5_G10, EPD0790_5_G12, EPD0790_5_H01, EPD0790_5_H04, EPD0790_5_H07, EPD0790_5_H08, EPD0790_5_H09, EPD0790_5_H10, EPD0790_5_H11, EPD0790_5_H12
Germline Transmission:  Earliest citation of germline transmission: J:175295
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: EUCOMM
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_Bact_P
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 20207692 of Chromosome 13 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 20208432. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:155845, J:173534)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Elmo1 Mutation:  13 strains or lines available
Original:  J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010;
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory