Sgms1^tm1Kenw
Targeted Allele Detail

Nomenclature

• Symbol: Sgms1^tm1Kenw
• Name: sphingomyelin synthase 1; targeted mutation 1, Ken Watanabe
• MGI ID: MGI:4939657
• Synonyms: Sgms1^tm1Yo, SMS1^-
• Gene: Sgms1 Location: Chr19:32122727-32389714 bp, - strand Genetic Position: Chr19, 26.68 cM

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168726
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exon 2 was replaced with a neo cassette. The absence of sphingomyelin synthase was confirmed by enzymatic assay. (J:168726)

Generation of the Sgms1^tm1Kenw allele

Expression

In Structures Affected by this Mutation:

4 anatomical structures

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Sgms1 Mutation: 204 strains or lines available

References

• Original: J:168726 Yano M, et al., Mitochondrial Dysfunction and Increased Reactive Oxygen Species Impair Insulin Secretion in Sphingomyelin Synthase 1-null Mice. J Biol Chem. 2011 Feb 4;286(5):3992-4002
• All: 5 reference(s)