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Sgms1tm1Kenw
Targeted Allele Detail
Nomenclature
Symbol: Sgms1tm1Kenw
Name: sphingomyelin synthase 1; targeted mutation 1, Ken Watanabe
MGI ID: MGI:4939657
Synonyms: Sgms1tm1Yo
Gene: Sgms1  Location: Chr19:32122727-32389714 bp, - strand  Genetic Position: Chr19, 26.68 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:168726
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 was replaced with a neo cassette. The absence of sphingomyelin synthase was confirmed by enzymatic assay. (J:168726)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Sgms1 Mutation:  215 strains or lines available
References
Original:  J:168726 Yano M, et al., Mitochondrial Dysfunction and Increased Reactive Oxygen Species Impair Insulin Secretion in Sphingomyelin Synthase 1-null Mice. J Biol Chem. 2011 Feb 4;286(5):3992-4002
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory