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Gt(ROSA)26Sortm1(CAG-Rheb*)Pfw
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm1(CAG-Rheb*)Pfw
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Paul Worley
MGI ID: MGI:4939476
Synonyms: Rosa26-Rheb1k
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077244 bp, - strand  Genetic Position: Chr6, 52.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:168571
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence)
Mutation:    Insertion
 
Gt(ROSA)26Sortm1(CAG-Rheb*)Pfw expresses 1 gene
 
Mutation detailsA construct consisting of the CMV beta-actin enhancer/promoter, a floxed PGK-EM7-neo-tPA cassette, a myc tagged Rheb cDNA containing an S16H mutation, and an SV40 poly(A) signal, was inserted via homologous recombination. Expression of the Rheb cDNA is silenced prior to cre mediated recombination. (J:168571)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  497 strains or lines available
References
Original:  J:168571 Zou J, et al., Rheb1 is required for mTORC1 and myelination in postnatal brain development. Dev Cell. 2011 Jan 18;20(1):97-108
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory