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S1pr1tm1Jch
Targeted Allele Detail
Nomenclature
Symbol: S1pr1tm1Jch
Name: sphingosine-1-phosphate receptor 1; targeted mutation 1, Jerold Chun
MGI ID: MGI:4939069
Synonyms: S1pr1loxP
Gene: S1pr1  Location: Chr3:115710433-115715072 bp, - strand  Genetic Position: Chr3, 50.0 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:168824
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
    The entrire open reading frame is flanked by loxP sites. (J:168824)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any S1pr1 Mutation:  13 strains or lines available
References
Original:  J:168824 Choi JW, et al., FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation. Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):751-6
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory