Tg(IVL-MAP2K1*S217E*S221E)3376AFmw
Transgene Detail

Summary

• Symbol: Tg(IVL-MAP2K1*S217E*S221E)3376AFmw
• Name: transgene insertion 3376A, Fiona M Watt
• MGI ID: MGI:4936855
• Synonyms: InvEE
• Transgene: Tg(IVL-MAP2K1*S217E*S221E)3376AFmw Location: unknown
• Alliance: Tg(IVL-MAP2K1*S217E*S221E)3376AFmw page

Transgene origin

• Strain of Origin: (CBA x C57BL/6)F1

Transgene description

• Transgene Type: Transgenic (Constitutively active, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A constitutively activated map 2 kinase kinase 1 having two point mutations causing Serine to glutamic acid residue changes at positions 217 and 221 was placed under the control of the involucrin promoter. Three founder lines are reported. Line 3376A has a high relative insert copy number. (J:92906)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:92906 Hobbs RM, et al., Expression of activated MEK1 in differentiating epidermal cells is sufficient to generate hyperproliferative and inflammatory skin lesions. J Invest Dermatol. 2004 Sep;123(3):503-15
• All: 6 reference(s)