Tg(Dct-mHELKK)1Rc
Transgene Detail

Summary

• Symbol: Tg(Dct-mHELKK)1Rc
• Name: transgene insertion 1, Richard J Cornall
• MGI ID: MGI:4889225
• Synonyms: Tg(DctmHELKK), TrpHEL, TrpHEL1
• Transgene: Tg(Dct-mHELKK)1Rc Location: unknown
• Alliance: Tg(Dct-mHELKK)1Rc page

Transgene origin

• Strain of Origin: C57BL/6 and CBA/Ca

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: Mice bearing this transgene express intracellular, membrane-bound hen egg lysozyme. Expression is driven specifically in melanocytes by the mouse dopachrome tautomerase (Dct; formerly Trp2) promoter. The lysozyme protein is anchored within the endoplasmic reticulum (ER) by the H2-k^b transmembrane domain that has been modified by addition of a dilysine ER retention signal. Two transgenic lines, designated TrpHEL1 and TrpHEL2, exhibited similar levels of expression in both skin and thymus, colocalized in skin with endogenous DCT. (J:139546)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:139546 Lambe T, et al., CD4 T cell-dependent autoimmunity against a melanocyte neoantigen induces spontaneous vitiligo and depends upon Fas-Fas ligand interactions. J Immunol. 2006 Sep 1;177(5):3055-62
• All: 1 reference(s)