Alox15^tm1.1Nadl
Targeted Allele Detail

Summary

• Symbol: Alox15^tm1.1Nadl
• Name: arachidonate 15-lipoxygenase; targeted mutation 1.1, Jerry Nadler
• MGI ID: MGI:4889210
• Synonyms: 12/15-LO^loxp, Alox15^Loxp
• Gene: Alox15 Location: Chr11:70234978-70242857 bp, - strand Genetic Position: Chr11, 42.99 cM
• Alliance: Alox15^tm1.1Nadl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:224344
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Development of this allele was contracted to Ozgene in Australia. Exons 2 to 5 were flanked by loxP sites. An FRT flanked neomycin selection cassette has been removed. (J:224344, J:258370)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Alox15 Mutation: 42 strains or lines available

References

• Original: J:258370 Cole BK, et al., Adipose tissue-specific deletion of 12/15-lipoxygenase protects mice from the consequences of a high-fat diet. Mediators Inflamm. 2012;2012:851798
• All: 8 reference(s)