Ipmk^tm1.1Snyd
Targeted Allele Detail

Summary

• Symbol: Ipmk^tm1.1Snyd
• Name: inositol polyphosphate multikinase; targeted mutation 1.1, Solomon Snyder
• MGI ID: MGI:4889097
• Synonyms: IPMK^flox
• Gene: Ipmk Location: Chr10:71183574-71221715 bp, + strand Genetic Position: Chr10, 36.89 cM, cytoband B5.2
• Alliance: Ipmk^tm1.1Snyd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168243
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 6. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 6. Flp-mediated recombination removed the neo cassette leaving exon 6 floxed. (J:168243)

Generation of the Ipmk^tm1.1Snyd and Ipmk^tm1.2Snyd alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ipmk Mutation: 30 strains or lines available

References

• Original: J:168243 Maag D, et al., Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB. Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1391-6
• All: 6 reference(s)