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Targeted Allele Detail
Symbol: Hcn4tm1.1Ggc
Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 4; targeted mutation 1.1, Giacomo Consalez
MGI ID: MGI:4888968
Synonyms: Hcn4lox, Hcn4tm1.1Ddf
Gene: Hcn4  Location: Chr9:58823512-58860955 bp, + strand  Genetic Position: Chr9, 31.8 cM, cytoband C
Germline Transmission:  Earliest citation of germline transmission: J:168248
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsAn FRT flanked neomycin selection cassette was inserted upstream of exon 2 and exon 2 was flanked with loxP sites. Mice were then crossed to transgenic mice expressing flp recombinase to excise the neomycin selection cassette. (J:168248)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hcn4 Mutation:  12 strains or lines available
Original:  J:168248 Baruscotti M, et al., Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4. Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1705-10
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
The Jackson Laboratory