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Lrp8tm1(KOMP)Mbp
Targeted Allele Detail
Summary
Symbol: Lrp8tm1(KOMP)Mbp
Name: low density lipoprotein receptor-related protein 8, apolipoprotein e receptor; targeted mutation 1, Mouse Biology Program, UC Davis
MGI ID: MGI:4888819
Gene: Lrp8  Location: Chr4:107659337-107734037 bp, + strand  Genetic Position: Chr4, 50.18 cM, cytoband C7
IMPC: Lrp8 gene page
Mutation
origin
Mutant Cell Lines:  DEPD00542_1_D01, DEPD00542_1_E04, DEPD00542_1_F03, DEPD00542_1_G03, DEPD00542_1_H04
Germline Transmission:  Unknown
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion     Vector: L1L2_Bact_P
 
Mutation detailsThe insertion of the L1L2_Bact_P cassette created a deletion of size 5463 starting at position 107703379 and ending at position 107708842 of Chromosome 4 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157064)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 1 line available
Carrying any Lrp8 Mutation:  43 strains or lines available
References
Original:  J:157064 University of California, Davis, Alleles produced for the KOMP project by the University of California, Davis. MGI Direct Data Submission. 2010;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory