Tg(MAPT*S305S)4Gds
Transgene Detail

Summary

• Symbol: Tg(MAPT*S305S)4Gds
• Name: transgene insertion 4, Gerard Schellenberg
• MGI ID: MGI:4888599
• Synonyms: ht-PAC-305S
• Transgene: Tg(MAPT*S305S)4Gds Location: unknown
• Alliance: Tg(MAPT*S305S)4Gds page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(MAPT*S305S)4Gds expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MAPT (4137)

  Mapt	(MGI:97180)

• Mutation details: The transgene contains the complete sequence of human MAPT gene as contained in the P1 artificial chromosome (PAC) 61D6 (Research Genetics, Huntsville, AL). This downstream segment contains the 3 prime end of the gene KIAA1267. MAPT is the only complete gene on this PAC. The S305S mutation was introduced into this PAC using a 2- step recombineering process. (J:152671)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:152671 McMillan P, et al., Tau isoform regulation is region- and cell-specific in mouse brain. J Comp Neurol. 2008 Dec 20;511(6):788-803
• All: 1 reference(s)