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Transgene Detail
Symbol: Tg(MAPT*S305S)4Gds
Name: transgene insertion 4, Gerard Schellenberg
MGI ID: MGI:4888599
Synonyms: ht-PAC-305S
Transgene: Tg(MAPT*S305S)4Gds  Location: unknown  
Strain of Origin:  Not Specified
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(MAPT*S305S)4Gds expresses 1 gene
Mutation detailsThe transgene contains the complete sequence of human MAPT gene as contained in the P1 artificial chromosome (PAC) 61D6 (Research Genetics, Huntsville, AL). This downstream segment contains the 3 prime end of the gene KIAA1267. MAPT is the only complete gene on this PAC. The S305S mutation was introduced into this PAC using a 2- step recombineering process. (J:152671)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:152671 McMillan P, et al., Tau isoform regulation is region- and cell-specific in mouse brain. J Comp Neurol. 2008 Dec 20;511(6):788-803
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory