Hprt1^{tm10(VWF-lacZ)Aird}
Targeted Allele Detail

Summary

• Symbol: Hprt1^{tm10(VWF-lacZ)Aird}
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 10, William C Aird
• MGI ID: MGI:4888497
• Synonyms: vWF2-delta843-620
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^{tm10(VWF-lacZ)Aird} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168401
• Parent Cell Line: BK4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A construct containing the human VWF promoter (-2182 to +1475 minus -843-620) adjoined to lacZ was targeted to the Hprt locus. Expression of lacZ by the VWF promoter was confirmed by whole mount staining of mutant embryos and postnatal mice. (J:168401)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1280 strains or lines available

References

• Original: J:168401 Liu J, et al., Vascular bed-specific regulation of the von Willebrand factor promoter in the heart and skeletal muscle. Blood. 2011 Jan 6;117(1):342-51
• All: 1 reference(s)