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Hprttm8(VWF-lacZ)Aird
Targeted Allele Detail
Nomenclature
Symbol: Hprttm8(VWF-lacZ)Aird
Name: hypoxanthine guanine phosphoribosyl transferase; targeted mutation 8, William C Aird
MGI ID: MGI:4888495
Synonyms: vWF2-Del3
Gene: Hprt  Location: ChrX:52988137-53021659 bp, + strand  Genetic Position: ChrX, 29.31 cM, cytoband A6
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:168401
Parent Cell Line:  BK4 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA construct containing the human VWF promoter (-620 to +1475) adjoined to lacZ was targeted to the Hprt locus. Expression of lacZ by the VWF promoter was confirmed by whole mount staining of mutant embryos and postnatal mice. (J:168401)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hprt Mutation:  1260 strains or lines available
References
Original:  J:168401 Liu J, et al., Vascular bed-specific regulation of the von Willebrand factor promoter in the heart and skeletal muscle. Blood. 2011 Jan 6;117(1):342-51
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory