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Cxcl12tm1.2Ystz
Targeted Allele Detail
Summary
Symbol: Cxcl12tm1.2Ystz
Name: C-X-C motif chemokine ligand 12; targeted mutation 1.2, Yi-Shiuan Tzeng
MGI ID: MGI:4888355
Gene: Cxcl12  Location: Chr6:117145496-117158328 bp, + strand  Genetic Position: Chr6, 54.81 cM, cytoband F1
Alliance: Cxcl12tm1.2Ystz page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:168434
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Cre-mediated recombination removed the neo cassette and exon 2. (J:168434)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cxcl12 Mutation:  24 strains or lines available
References
Original:  J:168434 Tzeng YS, et al., Loss of Cxcl12/Sdf-1 in adult mice decreases the quiescent state of hematopoietic stem/progenitor cells and alters the pattern of hematopoietic regeneration after myelosuppression. Blood. 2011 Jan 13;117(2):429-39
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory