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Targeted Allele Detail
Symbol: Dlg4tm4.1Grnt
Name: discs large MAGUK scaffold protein 4; targeted mutation 4.1, Seth G N Grant
MGI ID: MGI:4888250
Synonyms: PSD95SH3W470L
Gene: Dlg4  Location: Chr11:70017203-70045535 bp, + strand  Genetic Position: Chr11, 42.96 cM, cytoband B4
Germline Transmission:  Earliest citation of germline transmission: J:168384
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe exon encoding the SH3 domain was exchanged for a floxed neo cassette and a modified exon in which nucleotide substitutions result in the amino acid substitution of lysine for tryptophan at position 470 (W470L). Cre-mediated recombination removed the neo cassette. (J:168384)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dlg4 Mutation:  25 strains or lines available
Original:  J:168384 Arbuckle MI, et al., The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. EMBO Rep. 2010 Jun;11(6):473-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory