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Targeted Allele Detail
Symbol: Myh14tm1Rsad
Name: myosin, heavy polypeptide 14; targeted mutation 1, Robert S Adelstein
MGI ID: MGI:4887985
Synonyms: C-
Gene: Myh14  Location: Chr7:44605803-44670843 bp, - strand  Genetic Position: Chr7, 28.85 cM, cytoband B2
Germline Transmission:  Earliest citation of germline transmission: J:168304
Parent Cell Line:  CMT-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 0.3 kb fragment including the 157 bp exon 3 was replaced by a loxP-flanked neomycin resistance cassette via homologous recombination. Deletion of exon 3 was confirmed by Southern blot. Immunoblot analysis from lungs confirmed the absence of protein. (J:168304)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Myh14 Mutation:  47 strains or lines available
Original:  J:168304 Ma X, et al., Ablation of nonmuscle myosin II-B and II-C reveals a role for nonmuscle myosin II in cardiac myocyte karyokinesis. Mol Biol Cell. 2010 Nov;21(22):3952-62
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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