About   Help   FAQ
Thpotm1.1(TPO)Flv
Targeted Allele Detail
Nomenclature
Symbol: Thpotm1.1(TPO)Flv
Name: thrombopoietin; targeted mutation 1.1, Richard A Flavell
MGI ID: MGI:4887867
Synonyms: TPOh
Gene: Thpo  Location: Chr16:20543204-20553261 bp, - strand  Genetic Position: Chr16, 12.51 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:168301
Parent Cell Line:  V17 (ES Cell)
Strain of Origin:  BALB/cAnNTac x 129S4/SvJae
Mutation
description
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe coding region was replaced with the corresponding human sequence. Cre-mediated recombination removed the neo cassette. (J:168301)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Thpo Mutation:  16 strains or lines available
Notes
Originally generated in ES cells containing Il2rgtm1.1Flv and Rag2tm1.1Flv.
References
Original:  J:168301 Rongvaux A, et al., Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2378-83
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/16/2021
MGI 6.17
The Jackson Laboratory