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Gt(ROSA)26Sortm1.1(Otx2)Daac
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm1.1(Otx2)Daac
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Dario Acampora
MGI ID: MGI:4887449
Synonyms: R26Otx2
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:166896
Parent Cell Line:  E14TG2a.4 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence, Reporter)
Mutation:    Insertion
 
Gt(ROSA)26Sortm1.1(Otx2)Daac expresses 1 gene
 
Mutation detailsA vector containing a floxed neo/STOP cassette followed by the mouse cDNA and an IRES-GFP. Cre-mediated recombination removed the neo/STOP cassette. (J:166896)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  758 strains or lines available
References
Original:  J:166896 Di Salvio M, et al., Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP. Nat Neurosci. 2010 Dec;13(12):1481-8
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory