Nicol1^{tm1(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Nicol1^{tm1(EUCOMM)Wtsi}
• Name: NELL2 interacting cell ontogeny regulator 1; targeted mutation 1, Wellcome Trust Sanger Institute
• MGI ID: MGI:4882030
• Gene: Nicol1 Location: Chr5:34140863-34142353 bp, + strand Genetic Position: Chr5, 17.83 cM
• IMPC: Nicol1 gene page

Mutation origin

• Mutant Cell Line: EPD0710_3_D12
• Germline Transmission: Unknown
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: The insertion of the L1L2_Bact_P cassette created a deletion of size 1386 starting at position 34141029 and ending at position 34142415 of Chromosome 5 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. (J:155845, J:173534)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nicol1 Mutation: 18 strains or lines available

References

• Original: J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010
• All: 2 reference(s)