About   Help   FAQ
Triobptm1Tbf
Targeted Allele Detail
Nomenclature
Symbol: Triobptm1Tbf
Name: TRIO and F-actin binding protein; targeted mutation 1, Thomas B Friedman
MGI ID: MGI:4881773
Synonyms: Triobpdeltaexon8
Gene: Triobp  Location: Chr15:78947724-79005869 bp, + strand  Genetic Position: Chr15, 37.7 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:167947
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Modified isoform(s), Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsNearly all of exon 8 was replaced by a nlacZ reporter cassette and a floxed neo cassette, which was removed by cre-mediated recombination. The absence of isoform 5 transcript and isoform 4/5 proteins in the inner ear was confirmed by RT-PCR and western blot analysis respectively. Isoform 1 is retained. (J:167947)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Triobp Mutation:  5 strains or lines available
References
Original:  J:167947 Kitajiri S, et al., Actin-bundling protein TRIOBP forms resilient rootlets of hair cell stereocilia essential for hearing. Cell. 2010 May 28;141(5):786-98
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/26/2020
MGI 6.15
The Jackson Laboratory