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Targeted Allele Detail
Symbol: Triobptm1Tbf
Name: TRIO and F-actin binding protein; targeted mutation 1, Thomas B Friedman
MGI ID: MGI:4881773
Synonyms: Triobpdeltaexon8
Gene: Triobp  Location: Chr15:78947724-79005869 bp, + strand  Genetic Position: Chr15, 37.7 cM
Germline Transmission:  Earliest citation of germline transmission: J:167947
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Allele Type:    Targeted (Modified isoform(s), Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsNearly all of exon 8 was replaced by a nlacZ reporter cassette and a floxed neo cassette, which was removed by cre-mediated recombination. The absence of isoform 5 transcript and isoform 4/5 proteins in the inner ear was confirmed by RT-PCR and western blot analysis respectively. Isoform 1 is retained. (J:167947)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Triobp Mutation:  5 strains or lines available
Original:  J:167947 Kitajiri S, et al., Actin-bundling protein TRIOBP forms resilient rootlets of hair cell stereocilia essential for hearing. Cell. 2010 May 28;141(5):786-98
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
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