Otop1^ied
Chemically induced Allele Detail

Summary

• Symbol: Otop1^ied
• Name: otopetrin 1; inner ear defect
• MGI ID: MGI:4881519
• Gene: Otop1 Location: Chr5:38434748-38461560 bp, + strand Genetic Position: Chr5, 20.35 cM
• Alliance: Otop1^ied page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A T to A transversion was identified in the splicing donor site of exon 2. As a result of this change, splice varients a and b are absent. A modified splice variant c in which exon 1 is spliced directly to exon 3 rather than into exon 2, is found in the inner ear and testes. (J:103243)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Otop1 Mutation: 38 strains or lines available

References

• Original: J:103243 Besson V, et al., Training and aging modulate the loss-of-balance phenotype observed in a new ENU-induced allele of Otopetrin1. Biol Cell. 2005 Oct;97(10):787-98
• All: 2 reference(s)