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Daglatm1.1Kano
Targeted Allele Detail
Nomenclature
Symbol: Daglatm1.1Kano
Name: diacylglycerol lipase, alpha; targeted mutation 1.1, Masanobu Kano
MGI ID: MGI:4881474
Synonyms: alpha-KO, DGLalpha KO
Gene: Dagla  Location: Chr19:10245265-10304877 bp, - strand  Genetic Position: Chr19, 6.55 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:167891
Parent Cell Line:  RENKA (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 3, and an additional loxP site was inserted downstream of exon 4. Cre-mediated recombination removed the neo cassette and exons 3 and 4. The absence of protein expression was confirmed by immunohistochemistry on the brain. (J:167891)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dagla Mutation:  35 strains or lines available
References
Original:  J:167891 Tanimura A, et al., The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmission. Neuron. 2010 Feb 11;65(3):320-7
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/11/2017
MGI 6.10
The Jackson Laboratory