Fosl1^{tm1(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Fosl1^{tm1(EUCOMM)Wtsi}
• Name: fos-like antigen 1; targeted mutation 1, Wellcome Trust Sanger Institute
• MGI ID: MGI:4881077
• Gene: Fosl1 Location: Chr19:5497726-5505966 bp, + strand Genetic Position: Chr19, 4.33 cM
• IMPC: Fosl1 gene page

Mutation origin

• Mutant Cell Lines: EPD0711_2_A05, EPD0711_2_A06, EPD0711_2_B05, EPD0711_2_B06, EPD0711_2_B07, EPD0711_2_B08, EPD0711_2_C07, EPD0711_2_D06, EPD0711_2_D07, EPD0711_2_D08, EPD0711_2_E05, EPD0711_2_E06, EPD0711_2_E07, EPD0711_2_E08, EPD0711_2_F05, EPD0711_2_F06, EPD0711_2_F07, EPD0711_2_F08, EPD0711_2_G05, EPD0711_2_H05, EPD0711_2_H07, EPD0711_2_H08
• Germline Transmission: Unknown
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: The insertion of the L1L2_Bact_P cassette created a deletion of size 4474 starting at position 5500131 and ending at position 5504605 of Chromosome 19 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. (J:155845, J:173534)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fosl1 Mutation: 15 strains or lines available

References

• Original: J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010
• All: 2 reference(s)