Lat^{tm1(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Lat^{tm1(EUCOMM)Wtsi}
• Name: linker for activation of T cells; targeted mutation 1, Wellcome Trust Sanger Institute
• MGI ID: MGI:4881071
• Gene: Lat Location: Chr7:125962996-125968742 bp, - strand Genetic Position: Chr7, 69.01 cM
• IMPC: Lat gene page

Mutation origin

• Mutant Cell Lines: EPD0711_1_A05, EPD0711_1_B05, EPD0711_1_B06, EPD0711_1_B07, EPD0711_1_C06, EPD0711_1_C07, EPD0711_1_E05, EPD0711_1_E06, EPD0711_1_E07, EPD0711_1_E08, EPD0711_1_F06, EPD0711_1_H05, EPD0711_1_H06, EPD0711_1_H07, EPD0711_1_H08
• Germline Transmission: Unknown
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: The insertion of the L1L2_Bact_P cassette created a deletion of size 4848 starting at position 125963300 and ending at position 125968148 of Chromosome 7 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. (J:155845, J:173534)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lat Mutation: 11 strains or lines available

References

• Original: J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010
• All: 2 reference(s)