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Igf2tm1Snha
Targeted Allele Detail
Nomenclature
Symbol: Igf2tm1Snha
Name: insulin-like growth factor 2; targeted mutation 1, Sylvie N Hardouin
MGI ID: MGI:4880744
Synonyms: Igf2-P2-
Gene: Igf2  Location: Chr7:142650768-142666816 bp, - strand  Genetic Position: Chr7, 87.99 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:167738
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2, including the second alternate promoter, was replaced with a lacZ-neo cassette via homologous recombination. Real-time PCR analysis showed reduced total transcripts throughout development. However, no reduction in total protein level was detected during development. (J:167738)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igf2 Mutation:  7 strains or lines available
References
Original:  J:167738 Hardouin SN, et al., Impaired mesenchymal stem cell differentiation and osteoclastogenesis in mice deficient for Igf2-P2 transcripts. Development. 2011 Jan;138(2):203-13
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory