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Ing2tm1.1Ccha
Targeted Allele Detail
Nomenclature
Symbol: Ing2tm1.1Ccha
Name: inhibitor of growth family, member 2; targeted mutation 1.1, Curtis C Harri
MGI ID: MGI:4879096
Synonyms: Ing2-
Gene: Ing2  Location: Chr8:47667178-47675556 bp, - strand  Genetic Position: Chr8, 26.87 cM, cytoband B2
Testicular atrophy and semen abnormalities in Ing2tm1.1Ccha/Ing2tm1.1Ccha mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:167311
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA single loxp site was inserted into the first intron, followed by a neo cassette, flanked by two loxP sites. The neo cassette and the floxed exon 2 were removed by Cre-mediated recombination. (J:167311)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ing2 Mutation:  7 strains or lines available
References
Original:  J:167311 Saito M, et al., Targeted disruption of Ing2 results in defective spermatogenesis and development of soft-tissue sarcomas. PLoS One. 2010;5(11):e15541
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory