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Fli1tm1.1Morl
Targeted Allele Detail
Nomenclature
Symbol: Fli1tm1.1Morl
Name: Friend leukemia integration 1; targeted mutation 1.1, Francois Morle
MGI ID: MGI:4878922
Synonyms: Fli-1delta
Gene: Fli1  Location: Chr9:32422204-32542861 bp, - strand  Genetic Position: Chr9, 17.74 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:167426
Parent Cell Line:  ENS (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsTwo loxP sites were inserted flanking the coding sequence of exon 9 which contains the whole ETS DNA binding and C-terminal domains. This was followed by an FRT flanked neomycin resistance cassette. The selection cassette was subsequenty excised by transient flp expression. Exon 9 was then excised in the germline by cre expression. (J:167426)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fli1 Mutation:  5 strains or lines available
References
Original:  J:167426 Starck J, et al., Inducible Fli-1 gene deletion in adult mice modifies several myeloid lineage commitment decisions and accelerates proliferation arrest and terminal erythrocytic differentiation. Blood. 2010 Dec 2;116(23):4795-805
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory