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Atmintm1Axbe
Targeted Allele Detail
Nomenclature
Symbol: Atmintm1Axbe
Name: ATM interactor; targeted mutation 1, Axel Behrens
MGI ID: MGI:4868760
Synonyms: ATMINF
Gene: Atmin  Location: Chr8:116943393-116960445 bp, + strand  Genetic Position: Chr8, 63.37 cM
Decreased body size and reduced dopaminergic neurons in Atmintm1Axbe/Atmintm1Axbe Tg(Nes-cre)1Kln/0 mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:167331
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 4 and an FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 4. (J:167331)
Generation of the Atmintm1Axbe allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atmin Mutation:  3 strains or lines available
References
Original:  J:167331 Kanu N, et al., The ATM cofactor ATMIN protects against oxidative stress and accumulation of DNA damage in the aging brain. J Biol Chem. 2010 Dec 3;285(49):38534-42
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory