Mirc19^tm1.1Rhg
Targeted Allele Detail

Summary

• Symbol: Mirc19^tm1.1Rhg
• Name: microRNA cluster 19, including Mir212 through Mir132; targeted mutation 1.1, Richard H Goodman
• MGI ID: MGI:4868399
• Synonyms: Mir212/Mir132^tm1.1Rhg
• Gene: Mirc19 Location: unknown Genetic Position: Chr11, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166596
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Mutation details: A loxP and FRT-flanked neo cassette were inserted upstream of Mir212 and an additional loxP site was inserted downstream of exon Mir132. Cre-mediated recombination removed both microRNA sequences, 3 CREB-binding sites, and an RE1-silencing transcription factor (REST)-binding site. (J:166596)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mirc19 Mutation: 0 strains or lines available

References

• Original: J:166596 Magill ST, et al., microRNA-132 regulates dendritic growth and arborization of newborn neurons in the adult hippocampus. Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20382-7
• All: 6 reference(s)