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Targeted Allele Detail
Symbol: Rassf5tm1Sblee
Name: Ras association (RalGDS/AF-6) domain family member 5; targeted mutation 1, Sean Lee
MGI ID: MGI:4868223
Synonyms: Noer1-
Gene: Rassf5  Location: Chr1:131176410-131245178 bp, - strand  Genetic Position: Chr1, 56.91 cM
Rassf5tm1Sblee/Rassf5tm1Sblee mice are resistant to TNF-alpha-induced apoptosis

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:166871
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Exons 3, 4, and 5 were replaced with a floxed neomycin resistance cassette. (J:166871)
Generation of the Rassf5tm1Sblee allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rassf5 Mutation:  0 strains or lines available
Original:  J:166871 Park J, et al., Tumor suppressor ras association domain family 5 (RASSF5/NORE1) mediates death receptor ligand-induced apoptosis. J Biol Chem. 2010 Nov 5;285(45):35029-38
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory