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Rassf5tm1Sblee
Targeted Allele Detail
Nomenclature
Symbol: Rassf5tm1Sblee
Name: Ras association (RalGDS/AF-6) domain family member 5; targeted mutation 1, Sean Lee
MGI ID: MGI:4868223
Synonyms: Noer1-
Gene: Rassf5  Location: Chr1:131176410-131245178 bp, - strand  Genetic Position: Chr1, 56.91 cM
Rassf5tm1Sblee/Rassf5tm1Sblee mice are resistant to TNF-alpha-induced apoptosis

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:166871
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Exons 3, 4, and 5 were replaced with a floxed neomycin resistance cassette. (J:166871)
Generation of the Rassf5tm1Sblee allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rassf5 Mutation:  0 strains or lines available
References
Original:  J:166871 Park J, et al., Tumor suppressor ras association domain family 5 (RASSF5/NORE1) mediates death receptor ligand-induced apoptosis. J Biol Chem. 2010 Nov 5;285(45):35029-38
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory