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Csgalnact1tm1.1Migar
Targeted Allele Detail
Nomenclature
Symbol: Csgalnact1tm1.1Migar
Name: chondroitin sulfate N-acetylgalactosaminyltransferase 1; targeted mutation 1.1, Michihiro Igarashi
MGI ID: MGI:4868209
Gene: Csgalnact1  Location: Chr8:68356781-68735146 bp, - strand  Genetic Position: Chr8, 33.88 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:166870
Parent Cell Line:  RENKA (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 7, and an additional loxP site was inserted downstream of exon 7. Cre-mediated recombination removed exon 7 and the neo cassette. The absence of protein expression was confirmed by western blot analysis on E18.5 head extracts. (J:166870)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 14 assay results
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Csgalnact1 Mutation:  24 strains or lines available
References
Original:  J:166870 Watanabe Y, et al., Chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required for normal cartilage development. Biochem J. 2010 Oct 25;432(1):47-55
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory