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Targeted Allele Detail
Symbol: Spdeftm1Shiv
Name: SAM pointed domain containing ets transcription factor; targeted mutation 1, Ramesh Shivdasani
MGI ID: MGI:4867866
Gene: Spdef  Location: Chr17:27714352-27728950 bp, - strand  Genetic Position: Chr17, 14.59 cM, cytoband B1
Polypoid antral hyperplasia in Spdeftm1Shiv/Spdeftm1Shiv mice

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:166876
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 2-5 were replaced with a PGK-neomycin resistance cassette. This removed the transactivation domain, the Pointed domain, and most of the Ets DNA binding domain. Absence of protein was confirmed by immunostaining. (J:166876)
Generation of the Spdeftm1Shiv allele
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Spdef Mutation:  6 strains or lines available
Original:  J:166876 Horst D, et al., Requirement of the epithelium-specific Ets transcription factor Spdef for mucous gland cell function in the gastric antrum. J Biol Chem. 2010 Nov 5;285(45):35047-55
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
The Jackson Laboratory