Spdeftm1Shiv
Targeted Allele Detail
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Symbol: |
Spdeftm1Shiv |
Name: |
SAM pointed domain containing ets transcription factor; targeted mutation 1, Ramesh Shivdasani |
MGI ID: |
MGI:4867866 |
Gene: |
Spdef Location: Chr17:27933326-27947929 bp, - strand Genetic Position: Chr17, 14.59 cM, cytoband B1
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Alliance: |
Spdeftm1Shiv page
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Polypoid antral hyperplasia in Spdeftm1Shiv/Spdeftm1Shiv mice
Show the 4 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:166876
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Parent Cell Line: |
J1 (ES Cell)
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Strain of Origin: |
129S4/SvJae
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exons 2-5 were replaced with a PGK-neomycin resistance cassette. This removed the transactivation domain, the Pointed domain, and most of the Ets DNA binding domain. Absence of protein was confirmed by immunostaining.
(J:166876)
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Generation of the Spdeftm1Shiv allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Spdef Mutation: |
15 strains or lines available
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Original: |
J:166876 Horst D, et al., Requirement of the epithelium-specific Ets transcription factor Spdef for mucous gland cell function in the gastric antrum. J Biol Chem. 2010 Nov 5;285(45):35047-55 |
All: |
1 reference(s) |
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