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Targeted Allele Detail
Symbol: Spdeftm1Shiv
Name: SAM pointed domain containing ets transcription factor; targeted mutation 1, Ramesh Shivdasani
MGI ID: MGI:4867866
Gene: Spdef  Location: Chr17:27714352-27728950 bp, - strand  Genetic Position: Chr17, 14.59 cM, cytoband B1
Polypoid antral hyperplasia in Spdeftm1Shiv/Spdeftm1Shiv mice

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:166876
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 2-5 were replaced with a PGK-neomycin resistance cassette. This removed the transactivation domain, the Pointed domain, and most of the Ets DNA binding domain. Absence of protein was confirmed by immunostaining. (J:166876)
Generation of the Spdeftm1Shiv allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Spdef Mutation:  7 strains or lines available
Original:  J:166876 Horst D, et al., Requirement of the epithelium-specific Ets transcription factor Spdef for mucous gland cell function in the gastric antrum. J Biol Chem. 2010 Nov 5;285(45):35047-55
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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